Prediction of the next highly pathogenic avian influenza pandemic that can cause illness in humans
Identifieur interne : 000529 ( Main/Exploration ); précédent : 000528; suivant : 000530Prediction of the next highly pathogenic avian influenza pandemic that can cause illness in humans
Auteurs : Zhong-Wei Zhang [République populaire de Chine] ; Ting Liu [République populaire de Chine] ; Jian Zeng [République populaire de Chine] ; Yang-Er Chen [République populaire de Chine, Suède] ; Ming Yuan [République populaire de Chine, États-Unis] ; Da-Wei Zhang [République populaire de Chine, États-Unis] ; Feng Zhu [République populaire de Chine] ; Shu Yuan [République populaire de Chine]Source :
- Infectious Diseases of Poverty [ 2049-9957 ] ; 2015.
Descripteurs français
- KwdFr :
- ARN messager (), ARN messager (génétique), ARN viral, Alignement de séquences, Animaux, Biologie informatique, Conformation d'acide nucléique, Données de séquences moléculaires, Glycoprotéine hémagglutinine du virus influenza (), Glycoprotéine hémagglutinine du virus influenza (génétique), Grippe humaine (transmission), Grippe humaine (virologie), Grippe humaine (épidémiologie), Humains, Mutation, Pandémies, Phylogénie, Protéines virales (génétique), RNA replicase (génétique), Régions 5' non traduites, Séquence d'acides aminés, Virus de la grippe A (), Virus de la grippe A (génétique), Virus de la grippe A (pathogénicité).
- MESH :
- génétique : ARN messager, Glycoprotéine hémagglutinine du virus influenza, Protéines virales, RNA replicase, Virus de la grippe A.
- pathogénicité : Virus de la grippe A.
- virologie : Grippe humaine.
- épidémiologie : Grippe humaine.
- ARN messager, ARN viral, Alignement de séquences, Animaux, Biologie informatique, Conformation d'acide nucléique, Données de séquences moléculaires, Glycoprotéine hémagglutinine du virus influenza, Humains, Mutation, Pandémies, Phylogénie, Régions 5' non traduites, Séquence d'acides aminés, Virus de la grippe A.
English descriptors
- KwdEn :
- 5' Untranslated Regions, Amino Acid Sequence, Animals, Computational Biology, Hemagglutinin Glycoproteins, Influenza Virus (chemistry), Hemagglutinin Glycoproteins, Influenza Virus (genetics), Humans, Influenza A virus (classification), Influenza A virus (genetics), Influenza A virus (pathogenicity), Influenza, Human (epidemiology), Influenza, Human (transmission), Influenza, Human (virology), Molecular Sequence Data, Mutation, Nucleic Acid Conformation, Pandemics, Phylogeny, RNA Replicase (genetics), RNA, Messenger (chemistry), RNA, Messenger (genetics), RNA, Viral, Sequence Alignment, Viral Proteins (genetics).
- MESH :
- chemical , chemistry : Hemagglutinin Glycoproteins, Influenza Virus, RNA, Messenger.
- chemical , genetics : Hemagglutinin Glycoproteins, Influenza Virus, RNA Replicase, RNA, Messenger, Viral Proteins.
- chemical : 5' Untranslated Regions, RNA, Viral.
- classification : Influenza A virus.
- epidemiology : Influenza, Human.
- genetics : Influenza A virus.
- pathogenicity : Influenza A virus.
- transmission : Influenza, Human.
- virology : Influenza, Human.
- Amino Acid Sequence, Animals, Computational Biology, Humans, Molecular Sequence Data, Mutation, Nucleic Acid Conformation, Pandemics, Phylogeny, Sequence Alignment.
Abstract
In recent years, avian influenza viruses (AIVs) have seriously threatened human health. Questions such as: why do AIVs infect humans?, how quickly can an AIV become pandemic?, and which virus is the most dangerous? cannot be sufficiently answered using current bioinformatic studies.
Secondary structures and energies of representative 5′-untranslated region (UTR) of the
The simplicity of the secondary structure of the 5′-UTR of the
Some high-virulent strains of avian influenza might emerge in the next two to three years. The H2N2 subtype, once disappeared in humans, may stage a comeback. The current outbreak of H7N9 may become pandemic and cause even more deaths, if one or two bases are substituted in the 5′-UTR sequence of the
The online version of this article (doi:10.1186/s40249-015-0083-8) contains supplementary material, which is available to authorized users.
Url:
DOI: 10.1186/s40249-015-0083-8
PubMed: 26612517
PubMed Central: 4661964
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: 000180
- to stream Pmc, to step Curation: 000180
- to stream Pmc, to step Checkpoint: 000371
- to stream PubMed, to step Corpus: 000059
- to stream PubMed, to step Curation: 000059
- to stream PubMed, to step Checkpoint: 000062
- to stream Ncbi, to step Merge: 000C45
- to stream Ncbi, to step Curation: 000C45
- to stream Ncbi, to step Checkpoint: 000C45
- to stream Main, to step Merge: 000530
- to stream Main, to step Curation: 000529
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Prediction of the next highly pathogenic avian influenza pandemic that can cause illness in humans</title><author><name sortKey="Zhang, Zhong Wei" sort="Zhang, Zhong Wei" uniqKey="Zhang Z" first="Zhong-Wei" last="Zhang">Zhong-Wei Zhang</name><affiliation wicri:level="1"><nlm:aff id="Aff1">College of Resources Science and Technology, Sichuan Agricultural University, Chengdu, 611130 China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>College of Resources Science and Technology, Sichuan Agricultural University, Chengdu</wicri:regionArea><wicri:noRegion>Chengdu</wicri:noRegion></affiliation></author><author><name sortKey="Liu, Ting" sort="Liu, Ting" uniqKey="Liu T" first="Ting" last="Liu">Ting Liu</name><affiliation wicri:level="1"><nlm:aff id="Aff2">Sichuan Kelun Pharmaceutical Comp. Ltd., Chengdu, 610072 China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Sichuan Kelun Pharmaceutical Comp. Ltd., Chengdu</wicri:regionArea><wicri:noRegion>Chengdu</wicri:noRegion></affiliation></author><author><name sortKey="Zeng, Jian" sort="Zeng, Jian" uniqKey="Zeng J" first="Jian" last="Zeng">Jian Zeng</name><affiliation wicri:level="1"><nlm:aff id="Aff1">College of Resources Science and Technology, Sichuan Agricultural University, Chengdu, 611130 China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>College of Resources Science and Technology, Sichuan Agricultural University, Chengdu</wicri:regionArea><wicri:noRegion>Chengdu</wicri:noRegion></affiliation></author><author><name sortKey="Chen, Yang Er" sort="Chen, Yang Er" uniqKey="Chen Y" first="Yang-Er" last="Chen">Yang-Er Chen</name><affiliation wicri:level="1"><nlm:aff id="Aff3">Bioinformatic Study Centre, College of Life Sciences, Sichuan Agricultural University, Ya’an, 625014 China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Bioinformatic Study Centre, College of Life Sciences, Sichuan Agricultural University, Ya’an</wicri:regionArea><wicri:noRegion>Ya’an</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="Aff4">Department of Plant Physiology, Umeå University, SE-901 87 Umeå, Sweden</nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Plant Physiology, Umeå University, SE-901 87 Umeå</wicri:regionArea><wicri:noRegion>SE-901 87 Umeå</wicri:noRegion></affiliation></author><author><name sortKey="Yuan, Ming" sort="Yuan, Ming" uniqKey="Yuan M" first="Ming" last="Yuan">Ming Yuan</name><affiliation wicri:level="1"><nlm:aff id="Aff3">Bioinformatic Study Centre, College of Life Sciences, Sichuan Agricultural University, Ya’an, 625014 China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Bioinformatic Study Centre, College of Life Sciences, Sichuan Agricultural University, Ya’an</wicri:regionArea><wicri:noRegion>Ya’an</wicri:noRegion></affiliation><affiliation wicri:level="2"><nlm:aff id="Aff5">Boyce Thompson Institute, Cornell University, Ithaca, NY 14850 USA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">État de New York</region></placeName><wicri:cityArea>Boyce Thompson Institute, Cornell University, Ithaca</wicri:cityArea></affiliation></author><author><name sortKey="Zhang, Da Wei" sort="Zhang, Da Wei" uniqKey="Zhang D" first="Da-Wei" last="Zhang">Da-Wei Zhang</name><affiliation wicri:level="1"><nlm:aff id="Aff6">College of Life Sciences, Sichuan University, Chengdu, 610064 China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>College of Life Sciences, Sichuan University, Chengdu</wicri:regionArea><wicri:noRegion>Chengdu</wicri:noRegion></affiliation><affiliation wicri:level="2"><nlm:aff id="Aff7">Department of Genetics, Development and Cell Biology, Iowa State University, Ames, IA 50011 USA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Iowa</region></placeName><wicri:cityArea>Department of Genetics, Development and Cell Biology, Iowa State University, Ames</wicri:cityArea></affiliation></author><author><name sortKey="Zhu, Feng" sort="Zhu, Feng" uniqKey="Zhu F" first="Feng" last="Zhu">Feng Zhu</name><affiliation wicri:level="1"><nlm:aff id="Aff6">College of Life Sciences, Sichuan University, Chengdu, 610064 China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>College of Life Sciences, Sichuan University, Chengdu</wicri:regionArea><wicri:noRegion>Chengdu</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="Aff8">College of Horticulture and Plant Protection, Yangzhou University, Yangzhou, 225009 China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>College of Horticulture and Plant Protection, Yangzhou University, Yangzhou</wicri:regionArea><wicri:noRegion>Yangzhou</wicri:noRegion></affiliation></author><author><name sortKey="Yuan, Shu" sort="Yuan, Shu" uniqKey="Yuan S" first="Shu" last="Yuan">Shu Yuan</name><affiliation wicri:level="1"><nlm:aff id="Aff1">College of Resources Science and Technology, Sichuan Agricultural University, Chengdu, 611130 China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>College of Resources Science and Technology, Sichuan Agricultural University, Chengdu</wicri:regionArea><wicri:noRegion>Chengdu</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">26612517</idno><idno type="pmc">4661964</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4661964</idno><idno type="RBID">PMC:4661964</idno><idno type="doi">10.1186/s40249-015-0083-8</idno><date when="2015">2015</date><idno type="wicri:Area/Pmc/Corpus">000180</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000180</idno><idno type="wicri:Area/Pmc/Curation">000180</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000180</idno><idno type="wicri:Area/Pmc/Checkpoint">000371</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000371</idno><idno type="wicri:source">PubMed</idno><idno type="RBID">pubmed:26612517</idno><idno type="wicri:Area/PubMed/Corpus">000059</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000059</idno><idno type="wicri:Area/PubMed/Curation">000059</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000059</idno><idno type="wicri:Area/PubMed/Checkpoint">000062</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000062</idno><idno type="wicri:Area/Ncbi/Merge">000C45</idno><idno type="wicri:Area/Ncbi/Curation">000C45</idno><idno type="wicri:Area/Ncbi/Checkpoint">000C45</idno><idno type="wicri:Area/Main/Merge">000530</idno><idno type="wicri:Area/Main/Curation">000529</idno><idno type="wicri:Area/Main/Exploration">000529</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Prediction of the next highly pathogenic avian influenza pandemic that can cause illness in humans</title><author><name sortKey="Zhang, Zhong Wei" sort="Zhang, Zhong Wei" uniqKey="Zhang Z" first="Zhong-Wei" last="Zhang">Zhong-Wei Zhang</name><affiliation wicri:level="1"><nlm:aff id="Aff1">College of Resources Science and Technology, Sichuan Agricultural University, Chengdu, 611130 China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>College of Resources Science and Technology, Sichuan Agricultural University, Chengdu</wicri:regionArea><wicri:noRegion>Chengdu</wicri:noRegion></affiliation></author><author><name sortKey="Liu, Ting" sort="Liu, Ting" uniqKey="Liu T" first="Ting" last="Liu">Ting Liu</name><affiliation wicri:level="1"><nlm:aff id="Aff2">Sichuan Kelun Pharmaceutical Comp. Ltd., Chengdu, 610072 China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Sichuan Kelun Pharmaceutical Comp. Ltd., Chengdu</wicri:regionArea><wicri:noRegion>Chengdu</wicri:noRegion></affiliation></author><author><name sortKey="Zeng, Jian" sort="Zeng, Jian" uniqKey="Zeng J" first="Jian" last="Zeng">Jian Zeng</name><affiliation wicri:level="1"><nlm:aff id="Aff1">College of Resources Science and Technology, Sichuan Agricultural University, Chengdu, 611130 China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>College of Resources Science and Technology, Sichuan Agricultural University, Chengdu</wicri:regionArea><wicri:noRegion>Chengdu</wicri:noRegion></affiliation></author><author><name sortKey="Chen, Yang Er" sort="Chen, Yang Er" uniqKey="Chen Y" first="Yang-Er" last="Chen">Yang-Er Chen</name><affiliation wicri:level="1"><nlm:aff id="Aff3">Bioinformatic Study Centre, College of Life Sciences, Sichuan Agricultural University, Ya’an, 625014 China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Bioinformatic Study Centre, College of Life Sciences, Sichuan Agricultural University, Ya’an</wicri:regionArea><wicri:noRegion>Ya’an</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="Aff4">Department of Plant Physiology, Umeå University, SE-901 87 Umeå, Sweden</nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Plant Physiology, Umeå University, SE-901 87 Umeå</wicri:regionArea><wicri:noRegion>SE-901 87 Umeå</wicri:noRegion></affiliation></author><author><name sortKey="Yuan, Ming" sort="Yuan, Ming" uniqKey="Yuan M" first="Ming" last="Yuan">Ming Yuan</name><affiliation wicri:level="1"><nlm:aff id="Aff3">Bioinformatic Study Centre, College of Life Sciences, Sichuan Agricultural University, Ya’an, 625014 China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Bioinformatic Study Centre, College of Life Sciences, Sichuan Agricultural University, Ya’an</wicri:regionArea><wicri:noRegion>Ya’an</wicri:noRegion></affiliation><affiliation wicri:level="2"><nlm:aff id="Aff5">Boyce Thompson Institute, Cornell University, Ithaca, NY 14850 USA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">État de New York</region></placeName><wicri:cityArea>Boyce Thompson Institute, Cornell University, Ithaca</wicri:cityArea></affiliation></author><author><name sortKey="Zhang, Da Wei" sort="Zhang, Da Wei" uniqKey="Zhang D" first="Da-Wei" last="Zhang">Da-Wei Zhang</name><affiliation wicri:level="1"><nlm:aff id="Aff6">College of Life Sciences, Sichuan University, Chengdu, 610064 China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>College of Life Sciences, Sichuan University, Chengdu</wicri:regionArea><wicri:noRegion>Chengdu</wicri:noRegion></affiliation><affiliation wicri:level="2"><nlm:aff id="Aff7">Department of Genetics, Development and Cell Biology, Iowa State University, Ames, IA 50011 USA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Iowa</region></placeName><wicri:cityArea>Department of Genetics, Development and Cell Biology, Iowa State University, Ames</wicri:cityArea></affiliation></author><author><name sortKey="Zhu, Feng" sort="Zhu, Feng" uniqKey="Zhu F" first="Feng" last="Zhu">Feng Zhu</name><affiliation wicri:level="1"><nlm:aff id="Aff6">College of Life Sciences, Sichuan University, Chengdu, 610064 China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>College of Life Sciences, Sichuan University, Chengdu</wicri:regionArea><wicri:noRegion>Chengdu</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="Aff8">College of Horticulture and Plant Protection, Yangzhou University, Yangzhou, 225009 China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>College of Horticulture and Plant Protection, Yangzhou University, Yangzhou</wicri:regionArea><wicri:noRegion>Yangzhou</wicri:noRegion></affiliation></author><author><name sortKey="Yuan, Shu" sort="Yuan, Shu" uniqKey="Yuan S" first="Shu" last="Yuan">Shu Yuan</name><affiliation wicri:level="1"><nlm:aff id="Aff1">College of Resources Science and Technology, Sichuan Agricultural University, Chengdu, 611130 China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>College of Resources Science and Technology, Sichuan Agricultural University, Chengdu</wicri:regionArea><wicri:noRegion>Chengdu</wicri:noRegion></affiliation></author></analytic><series><title level="j">Infectious Diseases of Poverty</title><idno type="eISSN">2049-9957</idno><imprint><date when="2015">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>5' Untranslated Regions</term><term>Amino Acid Sequence</term><term>Animals</term><term>Computational Biology</term><term>Hemagglutinin Glycoproteins, Influenza Virus (chemistry)</term><term>Hemagglutinin Glycoproteins, Influenza Virus (genetics)</term><term>Humans</term><term>Influenza A virus (classification)</term><term>Influenza A virus (genetics)</term><term>Influenza A virus (pathogenicity)</term><term>Influenza, Human (epidemiology)</term><term>Influenza, Human (transmission)</term><term>Influenza, Human (virology)</term><term>Molecular Sequence Data</term><term>Mutation</term><term>Nucleic Acid Conformation</term><term>Pandemics</term><term>Phylogeny</term><term>RNA Replicase (genetics)</term><term>RNA, Messenger (chemistry)</term><term>RNA, Messenger (genetics)</term><term>RNA, Viral</term><term>Sequence Alignment</term><term>Viral Proteins (genetics)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>ARN messager ()</term><term>ARN messager (génétique)</term><term>ARN viral</term><term>Alignement de séquences</term><term>Animaux</term><term>Biologie informatique</term><term>Conformation d'acide nucléique</term><term>Données de séquences moléculaires</term><term>Glycoprotéine hémagglutinine du virus influenza ()</term><term>Glycoprotéine hémagglutinine du virus influenza (génétique)</term><term>Grippe humaine (transmission)</term><term>Grippe humaine (virologie)</term><term>Grippe humaine (épidémiologie)</term><term>Humains</term><term>Mutation</term><term>Pandémies</term><term>Phylogénie</term><term>Protéines virales (génétique)</term><term>RNA replicase (génétique)</term><term>Régions 5' non traduites</term><term>Séquence d'acides aminés</term><term>Virus de la grippe A ()</term><term>Virus de la grippe A (génétique)</term><term>Virus de la grippe A (pathogénicité)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>Hemagglutinin Glycoproteins, Influenza Virus</term><term>RNA, Messenger</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Hemagglutinin Glycoproteins, Influenza Virus</term><term>RNA Replicase</term><term>RNA, Messenger</term><term>Viral Proteins</term></keywords><keywords scheme="MESH" type="chemical" xml:lang="en"><term>5' Untranslated Regions</term><term>RNA, Viral</term></keywords><keywords scheme="MESH" qualifier="classification" xml:lang="en"><term>Influenza A virus</term></keywords><keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Influenza, Human</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Influenza A virus</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>ARN messager</term><term>Glycoprotéine hémagglutinine du virus influenza</term><term>Protéines virales</term><term>RNA replicase</term><term>Virus de la grippe A</term></keywords><keywords scheme="MESH" qualifier="pathogenicity" xml:lang="en"><term>Influenza A virus</term></keywords><keywords scheme="MESH" qualifier="pathogénicité" xml:lang="fr"><term>Virus de la grippe A</term></keywords><keywords scheme="MESH" qualifier="transmission" xml:lang="en"><term>Influenza, Human</term></keywords><keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Grippe humaine</term></keywords><keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Influenza, Human</term></keywords><keywords scheme="MESH" qualifier="épidémiologie" xml:lang="fr"><term>Grippe humaine</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Amino Acid Sequence</term><term>Animals</term><term>Computational Biology</term><term>Humans</term><term>Molecular Sequence Data</term><term>Mutation</term><term>Nucleic Acid Conformation</term><term>Pandemics</term><term>Phylogeny</term><term>Sequence Alignment</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>ARN messager</term><term>ARN viral</term><term>Alignement de séquences</term><term>Animaux</term><term>Biologie informatique</term><term>Conformation d'acide nucléique</term><term>Données de séquences moléculaires</term><term>Glycoprotéine hémagglutinine du virus influenza</term><term>Humains</term><term>Mutation</term><term>Pandémies</term><term>Phylogénie</term><term>Régions 5' non traduites</term><term>Séquence d'acides aminés</term><term>Virus de la grippe A</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Background</title><p>In recent years, avian influenza viruses (AIVs) have seriously threatened human health. Questions such as: why do AIVs infect humans?, how quickly can an AIV become pandemic?, and which virus is the most dangerous? cannot be sufficiently answered using current bioinformatic studies.</p></sec><sec><title>Method</title><p>Secondary structures and energies of representative 5′-untranslated region (UTR) of the <italic>HA</italic> gene were calculated. Then their secondary structures and energies were re-calculated after one or two nucleotide substitutions were introduced into the <italic>HA</italic> 5′-UTR. Phylogenetic trees on the basis of hemagglutinin (HA) and polymerase basic protein 2 (PB2) amino acid sequences and <italic>HA</italic> 5′-UTR nucleotide sequences were constructed. The connection between the energy and translation efficiency of 5′-UTR was confirmed by <italic>in vitro</italic> coupled transcription/translation assay.</p></sec><sec><title>Results</title><p>The simplicity of the secondary structure of the 5′-UTR of the <italic>HA</italic> gene determines the overall virus replication rate and transmission potential. Point mutation assays show that the 5′-UTR sequences of the <italic>HA</italic> gene in the influenza subtypes H2N2, H3N2, and H7N9 have greater variation potentials than other virus subtypes.</p></sec><sec><title>Conclusion</title><p>Some high-virulent strains of avian influenza might emerge in the next two to three years. The H2N2 subtype, once disappeared in humans, may stage a comeback. The current outbreak of H7N9 may become pandemic and cause even more deaths, if one or two bases are substituted in the 5′-UTR sequence of the <italic>HA</italic> gene.</p></sec><sec><title>Electronic supplementary material</title><p>The online version of this article (doi:10.1186/s40249-015-0083-8) contains supplementary material, which is available to authorized users.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Tumpey, Tm" uniqKey="Tumpey T">TM Tumpey</name></author><author><name sortKey="Basler, Cf" uniqKey="Basler C">CF Basler</name></author><author><name sortKey="Aguilar, Pv" uniqKey="Aguilar P">PV Aguilar</name></author><author><name sortKey="Zeng, H" uniqKey="Zeng H">H Zeng</name></author><author><name sortKey="Sol Rzano, A" uniqKey="Sol Rzano A">A Solórzano</name></author><author><name sortKey="Swayne, De" uniqKey="Swayne D">DE Swayne</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Smith, Gj" uniqKey="Smith G">GJ Smith</name></author><author><name sortKey="Bahl, J" uniqKey="Bahl J">J Bahl</name></author><author><name sortKey="Vijaykrishna, D" uniqKey="Vijaykrishna D">D Vijaykrishna</name></author><author><name sortKey="Zhang, J" uniqKey="Zhang J">J Zhang</name></author><author><name sortKey="Poon, Ll" uniqKey="Poon L">LL Poon</name></author><author><name sortKey="Chen, H" uniqKey="Chen H">H Chen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gao, Y" uniqKey="Gao Y">Y Gao</name></author><author><name sortKey="Zhang, Y" uniqKey="Zhang Y">Y Zhang</name></author><author><name sortKey="Shinya, K" uniqKey="Shinya K">K Shinya</name></author><author><name sortKey="Deng, G" uniqKey="Deng G">G Deng</name></author><author><name sortKey="Jiang, Y" uniqKey="Jiang Y">Y Jiang</name></author><author><name sortKey="Li, Z" uniqKey="Li Z">Z Li</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wang, W" uniqKey="Wang W">W Wang</name></author><author><name sortKey="Lu, B" uniqKey="Lu B">B Lu</name></author><author><name sortKey="Zhou, H" uniqKey="Zhou H">H Zhou</name></author><author><name sortKey="Suguitan, Al" uniqKey="Suguitan A">AL Suguitan</name></author><author><name sortKey="Cheng, X" uniqKey="Cheng X">X Cheng</name></author><author><name sortKey="Subbarao, K" uniqKey="Subbarao K">K Subbarao</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Imai, M" uniqKey="Imai M">M Imai</name></author><author><name sortKey="Watanabe, T" uniqKey="Watanabe T">T Watanabe</name></author><author><name sortKey="Hatta, M" uniqKey="Hatta M">M Hatta</name></author><author><name sortKey="Das, Sc" uniqKey="Das S">SC Das</name></author><author><name sortKey="Ozawa, M" uniqKey="Ozawa M">M Ozawa</name></author><author><name sortKey="Shinya, K" uniqKey="Shinya K">K Shinya</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zhang, Y" uniqKey="Zhang Y">Y Zhang</name></author><author><name sortKey="Zhang, Q" uniqKey="Zhang Q">Q Zhang</name></author><author><name sortKey="Kong, H" uniqKey="Kong H">H Kong</name></author><author><name sortKey="Jiang, Y" uniqKey="Jiang Y">Y Jiang</name></author><author><name sortKey="Gao, Y" uniqKey="Gao Y">Y Gao</name></author><author><name sortKey="Deng, G" uniqKey="Deng G">G Deng</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Shi, Y" uniqKey="Shi Y">Y Shi</name></author><author><name sortKey="Zhang, W" uniqKey="Zhang W">W Zhang</name></author><author><name sortKey="Wang, F" uniqKey="Wang F">F Wang</name></author><author><name sortKey="Qi, J" uniqKey="Qi J">J Qi</name></author><author><name sortKey="Wu, Y" uniqKey="Wu Y">Y Wu</name></author><author><name sortKey="Song, H" uniqKey="Song H">H Song</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zhang, Q" uniqKey="Zhang Q">Q Zhang</name></author><author><name sortKey="Shi, J" uniqKey="Shi J">J Shi</name></author><author><name sortKey="Deng, G" uniqKey="Deng G">G Deng</name></author><author><name sortKey="Guo, J" uniqKey="Guo J">J Guo</name></author><author><name sortKey="Zeng, X" uniqKey="Zeng X">X Zeng</name></author><author><name sortKey="He, X" uniqKey="He X">X He</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zhang, W" uniqKey="Zhang W">W Zhang</name></author><author><name sortKey="Shi, Y" uniqKey="Shi Y">Y Shi</name></author><author><name sortKey="Lu, X" uniqKey="Lu X">X Lu</name></author><author><name sortKey="Shu, Y" uniqKey="Shu Y">Y Shu</name></author><author><name sortKey="Qi, J" uniqKey="Qi J">J Qi</name></author><author><name sortKey="Gao, Gf" uniqKey="Gao G">GF Gao</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Resa Infante, P" uniqKey="Resa Infante P">P Resa-Infante</name></author><author><name sortKey="Jorbab, N" uniqKey="Jorbab N">N Jorbab</name></author><author><name sortKey="Coloma, R" uniqKey="Coloma R">R Coloma</name></author><author><name sortKey="Ortin, J" uniqKey="Ortin J">J Ortín</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tscherne, Dm" uniqKey="Tscherne D">DM Tscherne</name></author><author><name sortKey="Garcia Sastre, A" uniqKey="Garcia Sastre A">A García-Sastre</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Herfst, S" uniqKey="Herfst S">S Herfst</name></author><author><name sortKey="Schrauwen, Ej" uniqKey="Schrauwen E">EJ Schrauwen</name></author><author><name sortKey="Linster, M" uniqKey="Linster M">M Linster</name></author><author><name sortKey="Chutinimitkul, S" uniqKey="Chutinimitkul S">S Chutinimitkul</name></author><author><name sortKey="De Wit, E" uniqKey="De Wit E">E de Wit</name></author><author><name sortKey="Munster, Vj" uniqKey="Munster V">VJ Munster</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Russell, Ca" uniqKey="Russell C">CA Russell</name></author><author><name sortKey="Fonville, Jm" uniqKey="Fonville J">JM Fonville</name></author><author><name sortKey="Brown, Ae" uniqKey="Brown A">AE Brown</name></author><author><name sortKey="Burke, Df" uniqKey="Burke D">DF Burke</name></author><author><name sortKey="Smith, Dl" uniqKey="Smith D">DL Smith</name></author><author><name sortKey="James, Sl" uniqKey="James S">SL James</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lam, Tt" uniqKey="Lam T">TT Lam</name></author><author><name sortKey="Wang, J" uniqKey="Wang J">J Wang</name></author><author><name sortKey="Shen, Y" uniqKey="Shen Y">Y Shen</name></author><author><name sortKey="Zhou, B" uniqKey="Zhou B">B Zhou</name></author><author><name sortKey="Duan, L" uniqKey="Duan L">L Duan</name></author><author><name sortKey="Cheung, Cl" uniqKey="Cheung C">CL Cheung</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mehle, A" uniqKey="Mehle A">A Mehle</name></author><author><name sortKey="Doudna, Ja" uniqKey="Doudna J">JA Doudna</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Thompson, Jd" uniqKey="Thompson J">JD Thompson</name></author><author><name sortKey="Gibson, Tj" uniqKey="Gibson T">TJ Gibson</name></author><author><name sortKey="Plewniak, F" uniqKey="Plewniak F">F Plewniak</name></author><author><name sortKey="Jeanmougin, F" uniqKey="Jeanmougin F">F Jeanmougin</name></author><author><name sortKey="Higgins, Dg" uniqKey="Higgins D">DG Higgins</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Matzura, O" uniqKey="Matzura O">O Matzura</name></author><author><name sortKey="Wennborg, A" uniqKey="Wennborg A">A Wennborg</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Chursov, A" uniqKey="Chursov A">A Chursov</name></author><author><name sortKey="Kopetzky, Sj" uniqKey="Kopetzky S">SJ Kopetzky</name></author><author><name sortKey="Leshchiner, I" uniqKey="Leshchiner I">I Leshchiner</name></author><author><name sortKey="Kondofersky, I" uniqKey="Kondofersky I">I Kondofersky</name></author><author><name sortKey="Theis, Fj" uniqKey="Theis F">FJ Theis</name></author><author><name sortKey="Frishman, D" uniqKey="Frishman D">D Frishman</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Krieg, Pa" uniqKey="Krieg P">PA Krieg</name></author><author><name sortKey="Melton, Da" uniqKey="Melton D">DA Melton</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tamura, K" uniqKey="Tamura K">K Tamura</name></author><author><name sortKey="Stecher, G" uniqKey="Stecher G">G Stecher</name></author><author><name sortKey="Peterson, D" uniqKey="Peterson D">D Peterson</name></author><author><name sortKey="Filipski, A" uniqKey="Filipski A">A Filipski</name></author><author><name sortKey="Kumar, S" uniqKey="Kumar S">S Kumar</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Stegeman, A" uniqKey="Stegeman A">A Stegeman</name></author><author><name sortKey="Bouma, A" uniqKey="Bouma A">A Bouma</name></author><author><name sortKey="Elbers, Ar" uniqKey="Elbers A">AR Elbers</name></author><author><name sortKey="De Jong, Mc" uniqKey="De Jong M">MC de Jong</name></author><author><name sortKey="Nodelijk, G" uniqKey="Nodelijk G">G Nodelijk</name></author><author><name sortKey="De Klerk, F" uniqKey="De Klerk F">F de Klerk</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Shinya, K" uniqKey="Shinya K">K Shinya</name></author><author><name sortKey="Ebina, M" uniqKey="Ebina M">M Ebina</name></author><author><name sortKey="Yamada, S" uniqKey="Yamada S">S Yamada</name></author><author><name sortKey="Ono, M" uniqKey="Ono M">M Ono</name></author><author><name sortKey="Kasai, N" uniqKey="Kasai N">N Kasai</name></author><author><name sortKey="Kawaoka, Y" uniqKey="Kawaoka Y">Y Kawaoka</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Rossman, Js" uniqKey="Rossman J">JS Rossman</name></author><author><name sortKey="Lamb, Ra" uniqKey="Lamb R">RA Lamb</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="York, A" uniqKey="York A">A York</name></author><author><name sortKey="Fodor, E" uniqKey="Fodor E">E Fodor</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="De Smit, Mh" uniqKey="De Smit M">MH de Smit</name></author><author><name sortKey="Van Duin, J" uniqKey="Van Duin J">J van Duin</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Noble, E" uniqKey="Noble E">E Noble</name></author><author><name sortKey="Mathews, Dh" uniqKey="Mathews D">DH Mathews</name></author><author><name sortKey="Chen, Jl" uniqKey="Chen J">JL Chen</name></author><author><name sortKey="Turner, Dh" uniqKey="Turner D">DH Turner</name></author><author><name sortKey="Takimoto, T" uniqKey="Takimoto T">T Takimoto</name></author><author><name sortKey="Kim, B" uniqKey="Kim B">B Kim</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Yen, Hl" uniqKey="Yen H">HL Yen</name></author><author><name sortKey="Webster, Rg" uniqKey="Webster R">RG Webster</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Westgeest, Kb" uniqKey="Westgeest K">KB Westgeest</name></author><author><name sortKey="Russell, Ca" uniqKey="Russell C">CA Russell</name></author><author><name sortKey="Lin, X" uniqKey="Lin X">X Lin</name></author><author><name sortKey="Spronken, Mi" uniqKey="Spronken M">MI Spronken</name></author><author><name sortKey="Bestebroer, Tm" uniqKey="Bestebroer T">TM Bestebroer</name></author><author><name sortKey="Bahl, J" uniqKey="Bahl J">J Bahl</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Yang, Z" uniqKey="Yang Z">Z Yang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sorrell, Em" uniqKey="Sorrell E">EM Sorrell</name></author><author><name sortKey="Schrauwen, Ej" uniqKey="Schrauwen E">EJ Schrauwen</name></author><author><name sortKey="Linster, M" uniqKey="Linster M">M Linster</name></author><author><name sortKey="De Graaf, M" uniqKey="De Graaf M">M De Graaf</name></author><author><name sortKey="Herfst, S" uniqKey="Herfst S">S Herfst</name></author><author><name sortKey="Fouchier, Ra" uniqKey="Fouchier R">RA Fouchier</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Yuan, S" uniqKey="Yuan S">S Yuan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Yuan, S" uniqKey="Yuan S">S Yuan</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>République populaire de Chine</li><li>Suède</li><li>États-Unis</li></country><region><li>Iowa</li><li>État de New York</li></region></list><tree><country name="République populaire de Chine"><noRegion><name sortKey="Zhang, Zhong Wei" sort="Zhang, Zhong Wei" uniqKey="Zhang Z" first="Zhong-Wei" last="Zhang">Zhong-Wei Zhang</name></noRegion><name sortKey="Chen, Yang Er" sort="Chen, Yang Er" uniqKey="Chen Y" first="Yang-Er" last="Chen">Yang-Er Chen</name><name sortKey="Liu, Ting" sort="Liu, Ting" uniqKey="Liu T" first="Ting" last="Liu">Ting Liu</name><name sortKey="Yuan, Ming" sort="Yuan, Ming" uniqKey="Yuan M" first="Ming" last="Yuan">Ming Yuan</name><name sortKey="Yuan, Shu" sort="Yuan, Shu" uniqKey="Yuan S" first="Shu" last="Yuan">Shu Yuan</name><name sortKey="Zeng, Jian" sort="Zeng, Jian" uniqKey="Zeng J" first="Jian" last="Zeng">Jian Zeng</name><name sortKey="Zhang, Da Wei" sort="Zhang, Da Wei" uniqKey="Zhang D" first="Da-Wei" last="Zhang">Da-Wei Zhang</name><name sortKey="Zhu, Feng" sort="Zhu, Feng" uniqKey="Zhu F" first="Feng" last="Zhu">Feng Zhu</name><name sortKey="Zhu, Feng" sort="Zhu, Feng" uniqKey="Zhu F" first="Feng" last="Zhu">Feng Zhu</name></country><country name="Suède"><noRegion><name sortKey="Chen, Yang Er" sort="Chen, Yang Er" uniqKey="Chen Y" first="Yang-Er" last="Chen">Yang-Er Chen</name></noRegion></country><country name="États-Unis"><region name="État de New York"><name sortKey="Yuan, Ming" sort="Yuan, Ming" uniqKey="Yuan M" first="Ming" last="Yuan">Ming Yuan</name></region><name sortKey="Zhang, Da Wei" sort="Zhang, Da Wei" uniqKey="Zhang D" first="Da-Wei" last="Zhang">Da-Wei Zhang</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/H2N2V1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000529 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000529 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Sante
|area= H2N2V1
|flux= Main
|étape= Exploration
|type= RBID
|clé= PMC:4661964
|texte= Prediction of the next highly pathogenic avian influenza pandemic that can cause illness in humans
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:26612517" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \
| NlmPubMed2Wicri -a H2N2V1
| This area was generated with Dilib version V0.6.33. |  |